Effects of the Genetic Polymorphisms of CYP1A1 and GSTP1 on the Risk of Laryngeal Cancer in Koreans / 대한이비인후과학회지

BACKGROUND AND ackground and Objectives: Smoking has been reported as an important risk factor of laryngeal cancer. Cytochrome P450 1A1 (CYP1A1) and glutathione S-transferase P1 (GSTP1) are genes that encode enzymes which are involved in the metabolism of carcinogens in cigarette smoke. In this study, we statistically tested the significances of smoking and genotypes of CYP1A1 and GSTP1 as risk factors of laryngeal cancer. MATERIALS AND METHOD: In this case-control study, 84 pathologically proven laryngeal cancer patients and 168 age- and sex-matched controls were included as the study subjects. Information on smoking habit was collected using a self-administered questionnaire, and CYP1A1 and GSTP1 genotypes were analyzed using PCR-RFLP method. Chi-square test, Student's t-test and conditional logistic analysis were used to test statistical significance. RESULTS: Smoking was turned out to be a significant risk factor of laryngeal cancer both in univariate and multivariate analyses. The CYP1A1 Ile/Ile genotype was significant in the univariate test, but the statistical significance disappeared in the multivariate conditional logistic model including smoking. The odds ratio (95% confidence interval) of GSTP1 A/A genotype for laryngeal cancer was 0.71 (0.38, 1.33), which was not statistically significant. CONCLUSION: Smoking is the most potent risk factor among the three factors, and the genotypes of CYP1A1 and GSTP1 would not be major risk factors for laryngeal cancer in Koreans.

Pigmented Villonodular Synovitis of the Temporomandibular Joint: a case report / 대한이비인후과학회지

Pigmented villonodular synovitis is a benign proliferative disorder affecting the synovium. In 1941, Jaffe assembled under the common term of pigmented villonodular synovitis dissimilar lesions described by different names, that issuch as giant cell tumors of synovial tendon sheaths, actual pigmented villonodular synovitis, and villonodular bursitis. (Giant cell tumors of tendon sheaths, which may be localized, most often occurring in fingers, flexor tendons or interphalangeal joints, or diffuse, usually arising in the vicinity of large joints.) Involvement of the temporomandibular joint is very rare. (We report a rare case of pigmented villonodular synovitis of the temporomandibular joint that invaded the mandibular condyle. A 34-year-old man had a large left preauricular (parotid) mass for two years that he had focal facial nerve paralysis, temporal and zygomatic branches. The clinical appearance suggested a parotid tumor. At surgical exploration, a tumor was found to be severely adhered sion to the facial nerve and involving the temporomandibular joint. Histologically, Tthe resected specimen histologically was a proliferative lesion composed of epithelioid histiocytes, spindle cells, and multinucleated giant cells.) The appearance was typical of the family of lesions that includes pigmented villonodular synovitis, bursitis, and tenosynovitis . rewritten as follows: (Giant cell tumors of tendon sheaths, which may be localized, most often occurring in fingers, flexor tendons or interphalangeal joints, and spread to other parts after arising in the vicinity of large joints.) rewritten as follows: (A 34-year-old man had a large left preauricular (parotid) mass for two years and showed focal facial nerve paralysis in the temporal and zygomatic branches. The clinical appearance suggested a parotid tumor. Surgical exploration revealed a tumor that was severely connected to the facial nerve involving the temporomandibular joint. Histologically, the resected specimen was a proliferative lesion composed of epithelioid histiocytes, spindle cells, and multinucleated giant cells.)

A Clinical Study of Parathyroid Gland Tumors / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: Parathyroid gland tumor is a relatively rare disease in Korea. The purpose of our study is to assess the clinical features, diagnostic tools and therapeutic results. MATERIALS AND METHOD: Seven patients with parathyroid gland tumor were analyzed retrospectively. They were diagnosed and received surgical therapy in our hospital from 1995 to 1999. The patients were all female with mean age of 45.3 years (in the range of 21-64 years old). We used ultrasonography, computed tomography, magnetic resonance imaging, parathyroid scan and 18F-FDG positron emission tomograph (PET) to identify the location of parathyroid gland neoplasm. RESULTS: All patients received proper surgical management. Three patients were diagnosed as parathyroid carcinoma, three as parathyroid adenoma and one patient as cavernous hemangioma. Two patients were found as recurrent tumor, Parathyroid carcinoma recurred in one patient, and parathyroid hyperplasia occurred in patient who was previously diagnosed as parathyroid adenoma. CONCLUSION: The results would he a useful guideline for better diagnostic strategies, proper surgical management and follow-up study for recurrence in the parathyroid gland tumor.